“Hypervitaminosis” and “vitamin balance1”

Cxix. Hypervitaminosis and Vitamin

THE object of this paper is to record a continuation of experiments in which the existence is demonstrated of a "balance" between the vitamin B complex on the one hand and vitamins A and D of cod-liver oil on the other. Only two previous communications bearing directly on this subject have appeared in the literature, so far as we are aware. In the first place, Hopkins [1923] mentioned that he h...

Shifting of vitamin D deficiency to hypervitaminosis and toxicity.

Vitamin A absorption in cystic fibrosis: risk of hypervitaminosis A.

Vitamin A status was examined in nine adult cystic fibrosis patients and six adult control subjects, together with an assessment of their ability to absorb 10,000 IU of retinyl palmitate from a test meal, taken with appropriate pancreatic enzyme supplements. Median baseline values for plasma retinol and carotene, as well as median serum retinol binding protein concentrations, were significantly...

The Amelioration of Hypervitaminosis D in Rats with Vitamin A

The administration of relatively large amounts of vitamin A to hypervitaminotic D rats decreases the toxicity of this condition as evidenced by increased longevity, better weight gain, decreased soft tissue calcification and by considerable improvement in the histologic appearance of osseous structures.

Metabolism of retinol-binding protein and vitamin A during hypervitaminosis A in the rat.

Vitamin A is normally transported in plasma as retinol bound to a specific protein, retinol-binding protein (RBP). Detailed studies were conducted to examine the effects of excess vitamin A on the plasma concentration and metabolism of RBP, and to obtain information about vitamin A transport in the hypervitaminotic state. Two separate experiments were conducted. In the first (Study I, 99 days),...